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Gold-Leaf Treatment of Ischemic Skin Ulcers

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On 13 patients, 22 ischemic skin ulcers which had resisted a variety of therapeutic agents were treated with ordinary gold leaf. Three coexisting lesions served as controls. After initial cleansing and debridement, the ulcers were wetted with 95% alcohol, covered with four to eight layers of gold leaf, and protective dressings were applied; this procedure was repeated every 48 hours. A venous-stasis lesion decreased in size 86% in one month, and a diabetic ulcer showed 44% improvement in 11 days. Twenty decubitus ulcers decreased an average of 62%, and three coexisting control ulcers increased in size an average of 96%. Deterrents to successful treatment include a hemoglobin value below 12 gm/100 cc, excessive friction, undermining of ulcer edges, ringing of the lesion with scar tissue, and copious purulent discharge. No adverse reactions to gold leaf were observed.

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May 23, 1966
Gold-Leaf Treatment of Ischemic Skin Ulcers
Marion Wolf; Paul C. Wheeler, MD; Lester E. Wolcott, MD
JAMA. 1966;196(8):693-696. doi:10.1001/jama.1966.03100210063016